Version 5.4
Homo sapiens Gene: USP34
Summary
InnateDB Gene IDBG-53292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP34
Gene Name ubiquitin specific peptidase 34
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115464
Encoded Proteins
IDBP-232645
ubiquitin specific peptidase 34
IDBP-377233
ubiquitin specific peptidase 34
IDBP-377234
ubiquitin specific peptidase 34
IDBP-377237
ubiquitin specific peptidase 34
IDBP-377246
ubiquitin specific peptidase 34
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:61187463-61470769
Strand Reverse strand
Band p15
Transcripts
ENST00000398571 ENSP00000381577
ENST00000411912 ENSP00000398960
ENST00000436269 ENSP00000398489
ENST00000453734 ENSP00000410559
ENST00000453133 ENSP00000388129
ENST00000492604
ENST00000463046
ENST00000490552
ENST00000498268
ENST00000476716
ENST00000467128
ENST00000472689
ENST00000472706
ENST00000490527
ENST00000483672
ENST00000482250
ENST00000487547
ENST00000468703
ENST00000492882
ENST00000484179
ENST00000494867
ENST00000460004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005488 binding
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016055 Wnt signaling pathway
GO:0016579 protein deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056342
View Gene Order
ENSBTAG00000006027
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.609344 Hs.644708 Hs.714529
RefSeq NM_014709
HUGO
OMIM
CCDS CCDS42686
HPRD 11665
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca