InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP34

Summary

InnateDB Protein

IDBP-377237.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP34

Protein Name

ubiquitin specific peptidase 34

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410559

InnateDB Gene

IDBG-53292 (USP34)

Protein Structure

UniProt Annotation

Function

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269PubMed:21383061}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain at low level. {ECO:0000269PubMed:14715245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016055	Wnt signaling pathway
GO:0016579	protein deubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:0090263	positive regulation of canonical Wnt signaling pathway