Homo sapiens Gene: PLCB3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-53348.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PLCB3 | ||||||||||||||||||||||
Gene Name | phospholipase C, beta 3 (phosphatidylinositol-specific) | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000149782 | ||||||||||||||||||||||
Encoded Proteins |
phospholipase C, beta 3 (phosphatidylinositol-specific)
phospholipase C, beta 3 (phosphatidylinositol-specific)
phospholipase C, beta 3 (phosphatidylinositol-specific)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:64251523-64269150 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q13.1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G beta:gamma signalling through PLC beta pathway
PLC beta mediated events pathway
Opioid Signalling pathway
Presynaptic function of Kainate receptors pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Acetylcholine regulates insulin secretion pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Activation of Kainate Receptors upon glutamate binding pathway
Free fatty acids regulate insulin secretion pathway
Transmission across Chemical Synapses pathway
Inositol phosphate metabolism pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
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KEGG |
GnRH signaling pathway pathway
Gap junction pathway
Wnt signaling pathway pathway
Inositol phosphate metabolism pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Phosphatidylinositol signaling system pathway
Long-term depression pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Huntington's disease pathway
Gastric acid secretion pathway
Amoebiasis pathway
Chagas disease (American trypanosomiasis) pathway
Pancreatic secretion pathway
Salivary secretion pathway
African trypanosomiasis pathway
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INOH |
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
Inositol phosphate metabolism pathway
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PID NCI |
IL8- and CXCR2-mediated signaling events
LPA receptor mediated events
IL8- and CXCR1-mediated signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.523761 | ||||||||||||||||||||||
RefSeq | NM_000932 NM_001184883 XM_005274052 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS53654 CCDS8064 | ||||||||||||||||||||||
HPRD | 02577 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||