Mus musculus Gene: Plcb3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-137388.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Plcb3 | ||||||||||||||||||||||
Gene Name | phospholipase C, beta 3 | ||||||||||||||||||||||
Synonyms | mKIAA4098 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000024960 | ||||||||||||||||||||||
Encoded Proteins |
phospholipase C, beta 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149782:
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 19:6953714-6969759 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
GPCR downstream signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Integration of energy metabolism pathway
G beta:gamma signalling through PLC beta pathway
Activation of Kainate Receptors upon glutamate binding pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Acetylcholine regulates insulin secretion pathway
beta-catenin independent WNT signaling pathway
Metabolism pathway
Regulation of insulin secretion pathway
Ca2+ pathway pathway
Neuronal System pathway
G alpha (q) signalling events pathway
Opioid Signalling pathway
Presynaptic function of Kainate receptors pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Free fatty acids regulate insulin secretion pathway
Transmission across Chemical Synapses pathway
PLC beta mediated events pathway
G-protein mediated events pathway
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KEGG |
Calcium signaling pathway pathway
Alzheimer's disease pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Gap junction pathway
Phosphatidylinositol signaling system pathway
GnRH signaling pathway pathway
Long-term potentiation pathway
Long-term depression pathway
Inositol phosphate metabolism pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Huntington's disease pathway
Amoebiasis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Pancreatic secretion pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
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INOH |
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G beta:gamma signalling through PLC beta pathway
PLC beta mediated events pathway
Opioid Signalling pathway
Presynaptic function of Kainate receptors pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Acetylcholine regulates insulin secretion pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Activation of Kainate Receptors upon glutamate binding pathway
Free fatty acids regulate insulin secretion pathway
Transmission across Chemical Synapses pathway
Inositol phosphate metabolism pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
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KEGG |
GnRH signaling pathway pathway
Gap junction pathway
Wnt signaling pathway pathway
Inositol phosphate metabolism pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Phosphatidylinositol signaling system pathway
Long-term depression pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Huntington's disease pathway
Gastric acid secretion pathway
Amoebiasis pathway
Chagas disease (American trypanosomiasis) pathway
Pancreatic secretion pathway
Salivary secretion pathway
African trypanosomiasis pathway
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INOH |
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
Inositol phosphate metabolism pathway
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PID NCI |
IL8- and CXCR2-mediated signaling events
LPA receptor mediated events
IL8- and CXCR1-mediated signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | P51432 | ||||||||||||||||||||||
TrEMBL | Q8C8I0 Q9R1Y4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 18797 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001290349 NM_008874 XM_006526765 XM_006526766 XM_006526767 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS70925 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:104778 | ||||||||||||||||||||||
MGI Symbol | Plcb3 | ||||||||||||||||||||||
EMBL | AF022803 AK047029 AK146793 CH466612 U43144 | ||||||||||||||||||||||
GenPept | AAA85199 AAD01751 BAC32944 BAE27436 EDL33267 | ||||||||||||||||||||||
RNA Seq Atlas | 18797 | ||||||||||||||||||||||