Homo sapiens Gene: TFDP1
InnateDB Gene IDBG-53460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFDP1
Gene Name transcription factor Dp-1
Synonyms Dp-1; DP1; DRTF1
Species Homo sapiens
Ensembl Gene ENSG00000198176
Encoded Proteins
transcription factor Dp-1
transcription factor Dp-1
transcription factor Dp-1
transcription factor Dp-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113584721-113641470
Strand Forward strand
Band q34
ENST00000375370 ENSP00000364519
ENST00000408980 ENSP00000386145
ENST00000453989 ENSP00000401389
ENST00000544902 ENSP00000438450
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 53 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
GO:0008544 epidermis development
GO:0010467 gene expression
GO:0043276 anoikis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000278 regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
TGF_beta_Receptor pathway
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
Cyclin D associated events in G1 pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Pre-NOTCH Transcription and Translation pathway
Activation of NOXA and translocation to mitochondria pathway
Activation of PUMA and translocation to mitochondria pathway
Generic Transcription Pathway pathway
G1 Phase pathway
Cellular responses to stress pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Oncogene Induced Senescence pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Pre-NOTCH Expression and Processing pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Mitotic G1-G1/S phases pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Intrinsic Pathway for Apoptosis pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
TGF-beta signaling pathway pathway
Cell cycle pathway
Regulation of retinoblastoma protein
Direct p53 effectors
E2F transcription factor network
Regulation of nuclear SMAD2/3 signaling
UniProt Splice Variant
Entrez Gene
UniGene Hs.79353
RefSeq NM_007111 XM_005268326 XM_005268327 XM_005268328
HPRD 01792
RNA Seq Atlas