InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL1RAPL1

Summary

InnateDB Gene

IDBG-53480.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RAPL1

Gene Name

interleukin 1 receptor accessory protein-like 1

Synonyms

IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2

Species

Homo sapiens

Ensembl Gene

ENSG00000169306

Encoded Proteins

IDBP-53482

interleukin 1 receptor accessory protein-like 1

IDBP-53484

interleukin 1 receptor accessory protein-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25654981

IL37 acts as an extracellular cytokine to inhibit innate inflammation by binding to IL18R1 and then using IL1RAPL1 for its anti-inflammatory properties.

Entrez Gene

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:28587399-29956723

Strand

Forward strand

Band

p21.3

Transcripts

ENST00000378993	ENSP00000368278
ENST00000302196	ENSP00000305200

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007165	signal transduction
GO:0010975	regulation of neuron projection development
GO:0030182	neuron differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045920	negative regulation of exocytosis
GO:0050775	positive regulation of dendrite morphogenesis
GO:0070588	calcium ion transmembrane transport
GO:0097105	presynaptic membrane assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000052372

View Gene Order

Cross-References

SwissProt

Q9NZN1

TrEMBL

Q7Z2H0 X5DNQ7

UniProt Splice Variant

Entrez Gene

11141

UniGene

Hs.658912

RefSeq

NM_014271 XM_005274441

HUGO

HGNC:5996

OMIM

300206

CCDS

CCDS14218

HPRD

IMGT

EMBL

AB101891 AB101892 AB101893 AB101894 AB101895 AB101896 AB101897 AB101898 AB101899 AB101901 AB101902 AB101903 AB101904 AB101905 AB101906 AB101907 AB101908 AB101909 AB101910 AB102650 AC005748 AC121343 AC129852 AF181284 AF284435 AJ243874 AL031466 AL031575 BC126345 BC126347 CH471074 KJ534871

GenPept

AAF59411 AAG21369 AAI26346 AAI26348 AHW56511 BAC80450 BAC80451 BAC80452 BAC80453 BAC80454 BAC80455 BAC80456 BAC80457 BAC80458 BAC80460 BAC80461 BAC80462 BAC80463 BAC80464 BAC80465 BAC80466 BAC80467 BAC80468 BAC80469 BAC81119 CAB56046 CAI42035 CAI42992 EAW99046

RNA Seq Atlas

11141