Homo sapiens Gene: PAK7
Summary
InnateDB Gene IDBG-53557.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK7
Gene Name p21 protein (Cdc42/Rac)-activated kinase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101349
Encoded Proteins
p21 protein (Cdc42/Rac)-activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:9537389-9839041
Strand Reverse strand
Band p12.2
Transcripts
ENST00000378429 ENSP00000367686
ENST00000353224 ENSP00000322957
ENST00000378423 ENSP00000367679
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007612 learning
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008283 cell proliferation
GO:0016049 cell growth
GO:0016477 cell migration
GO:0023014 signal transduction by phosphorylation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Axon guidance pathway
Activation of Rac pathway
Signaling by Robo receptor pathway
KEGG
ErbB signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Renal cell carcinoma pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.32539
RefSeq NM_020341 NM_177990 XM_005260766 XM_006723597
HUGO
OMIM
CCDS CCDS13107
HPRD 06423
IMGT
EMBL
GenPept
RNA Seq Atlas