Homo sapiens Gene: ATP4B
Summary
InnateDB Gene IDBG-53569.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP4B
Gene Name ATPase, H+/K+ exchanging, beta polypeptide
Synonyms ATP6B
Species Homo sapiens
Ensembl Gene ENSG00000186009
Encoded Proteins
ATPase, H+/K+ exchanging, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113648804-113658186
Strand Reverse strand
Band q34
Transcripts
ENST00000335288 ENSP00000334216
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008900 hydrogen:potassium-exchanging ATPase activity
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007155 cell adhesion
GO:0010243 response to organonitrogen compound
GO:0032496 response to lipopolysaccharide
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Ion transport by P-type ATPases pathway
Transmembrane transport of small molecules pathway
Ion channel transport pathway
KEGG
Oxidative phosphorylation pathway
Gastric acid secretion pathway
Collecting duct acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt P51164
TrEMBL
UniProt Splice Variant
Entrez Gene 496
UniGene Hs.434202
RefSeq NM_000705
HUGO HGNC:820
OMIM 137217
CCDS CCDS9539
HPRD
IMGT
EMBL AB008783 BC029059 BX537316 CH471085 M75110
GenPept AAA35987 AAH29059 BAA23425 CAM28358 EAX09221
RNA Seq Atlas 496