Version 5.4
Homo sapiens Gene: GAS6
Summary
InnateDB Gene IDBG-53634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAS6
Gene Name growth arrest-specific 6
Synonyms AXLLG; AXSF
Species Homo sapiens
Ensembl Gene ENSG00000183087
Encoded Proteins
IDBP-53636
growth arrest-specific 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 11948660
GAS6 is a ligand for all members of the TAM receptor tyrosine kinase family, each of which has different affinities to GAS6.
PMID 16723520
GAS6 signals through the AXL receptor and the PI3-kinase/Akt1 survival pathway, protecting oligodendrocytes from growth factor withdrawal and TNF-alpha-mediated cell death.
PMID 22043818
GAS6 works with PROS1 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22043818
[Mus musculus] Gas6 works with Pros1 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages.
Entrez Gene
Summary This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113820549-113864067
Strand Reverse strand
Band q34
Transcripts
ENST00000327773 ENSP00000331831
ENST00000480426
ENST00000476291
ENST00000608763
ENST00000610073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0005102 receptor binding
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030296 protein tyrosine kinase activator activity
GO:0030971 receptor tyrosine kinase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0048018 receptor agonist activity
GO:0060090 binding, bridging
Biological Process
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002576 platelet degranulation
GO:0003104 positive regulation of glomerular filtration
GO:0006468 protein phosphorylation
GO:0006508 proteolysis
GO:0006909 phagocytosis
GO:0007050 cell cycle arrest
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0009267 cellular response to starvation
GO:0010628 positive regulation of gene expression
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010934 macrophage cytokine production
GO:0016477 cell migration
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019079 viral genome replication
GO:0030168 platelet activation
GO:0031100 organ regeneration
GO:0031589 cell-substrate adhesion
GO:0032008 positive regulation of TOR signaling
GO:0032148 activation of protein kinase B activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033159 negative regulation of protein import into nucleus, translocation
GO:0035457 cellular response to interferon-alpha
GO:0035690 cellular response to drug
GO:0035754 B cell chemotaxis
GO:0040008 regulation of growth
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043277 apoptotic cell clearance
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043491 protein kinase B signaling
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046718 viral entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0046827 positive regulation of protein export from nucleus
GO:0048146 positive regulation of fibroblast proliferation
GO:0050711 negative regulation of interleukin-1 secretion
GO:0050766 positive regulation of phagocytosis
GO:0050900 leukocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070168 negative regulation of biomineral tissue development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0070588 calcium ion transmembrane transport
GO:0071307 cellular response to vitamin K
GO:0071333 cellular response to glucose stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0072661 protein targeting to plasma membrane
GO:0085029 extracellular matrix assembly
GO:0097028 dendritic cell differentiation
GO:0097241 hematopoietic stem cell migration to bone marrow
GO:1900142 negative regulation of oligodendrocyte apoptotic process
GO:1900165 negative regulation of interleukin-6 secretion
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000510 positive regulation of dendritic cell chemotaxis
GO:2000533 negative regulation of renal albumin absorption
GO:2000669 negative regulation of dendritic cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031451
View Gene Order
ENSBTAG00000019964
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_1050
Gamma-carboxylation of protein precursors pathway
REACT_1906
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_733
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_1132
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_17015
Metabolism of proteins pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q14393
TrEMBL B4DZY7
UniProt Splice Variant
Entrez Gene 2621
UniGene
RefSeq NM_000820
HUGO HGNC:4168
OMIM 600441
CCDS CCDS45072
HPRD
IMGT
EMBL AK092028 AK122969 AK126533 AK290803 AK303145 AY170372 AY256830 AY256831 AY256832 AY256833 AY256834 AY256835 AY256836 AY256837 AY256838 AY256839 AY256840 AY256841 AY256842 AY256843 BC038984 BK001240 BX072579 EF631974 L13720
GenPept AAA58494 AAH38984 AAO41859 AAO84057 ABR09277 BAC86580 BAF83492 BAG52469 BAG53826 BAG64249 CAH71174 DAA01155
RNA Seq Atlas 2621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca