InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAS6

Summary

InnateDB Protein

IDBP-53636.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAS6

Protein Name

growth arrest-specific 6

Synonyms

AXLLG; AXSF;

Species

Homo sapiens

Ensembl Protein

ENSP00000331831

InnateDB Gene

IDBG-53634 (GAS6)

Protein Structure

UniProt Annotation

Function

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269PubMed:12364394, ECO:0000269PubMed:18840707}.

Subcellular Localization

Secreted {ECO:0000269PubMed:9326369}.

Disease Associations

Tissue Specificity

Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. {ECO:0000269PubMed:8336730, ECO:0000269PubMed:9326368}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005102	receptor binding
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030296	protein tyrosine kinase activator activity
GO:0030971	receptor tyrosine kinase binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0048018	receptor agonist activity
GO:0060090	binding, bridging

Biological Process

GO:0001764	neuron migration
GO:0001934	positive regulation of protein phosphorylation
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0002576	platelet degranulation
GO:0003104	positive regulation of glomerular filtration
GO:0006468	protein phosphorylation
GO:0006508	proteolysis
GO:0006909	phagocytosis
GO:0007050	cell cycle arrest
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0009267	cellular response to starvation
GO:0010628	positive regulation of gene expression
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010934	macrophage cytokine production
GO:0016477	cell migration
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0018105	peptidyl-serine phosphorylation
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0019079	viral genome replication
GO:0030168	platelet activation
GO:0031100	organ regeneration
GO:0031589	cell-substrate adhesion
GO:0032008	positive regulation of TOR signaling
GO:0032148	activation of protein kinase B activity
GO:0032689	negative regulation of interferon-gamma production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032825	positive regulation of natural killer cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033159	negative regulation of protein import into nucleus, translocation
GO:0035457	cellular response to interferon-alpha
GO:0035690	cellular response to drug
GO:0035754	B cell chemotaxis
GO:0040008	regulation of growth
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043277	apoptotic cell clearance
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043491	protein kinase B signaling
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046718	viral entry into host cell
GO:0046813	receptor-mediated virion attachment to host cell
GO:0046827	positive regulation of protein export from nucleus
GO:0048146	positive regulation of fibroblast proliferation
GO:0050711	negative regulation of interleukin-1 secretion
GO:0050766	positive regulation of phagocytosis
GO:0050900	leukocyte migration
GO:0051897	positive regulation of protein kinase B signaling
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0070168	negative regulation of biomineral tissue development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:0070588	calcium ion transmembrane transport
GO:0071307	cellular response to vitamin K
GO:0071333	cellular response to glucose stimulus
GO:0071363	cellular response to growth factor stimulus
GO:0072661	protein targeting to plasma membrane
GO:0085029	extracellular matrix assembly
GO:0097028	dendritic cell differentiation
GO:0097241	hematopoietic stem cell migration to bone marrow
GO:1900142	negative regulation of oligodendrocyte apoptotic process
GO:1900165	negative regulation of interleukin-6 secretion
GO:2000270	negative regulation of fibroblast apoptotic process
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2000510	positive regulation of dendritic cell chemotaxis
GO:2000533	negative regulation of renal albumin absorption
GO:2000669	negative regulation of dendritic cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00594
PF00008
PF00054
PF02210
PF07645

PRINTS

PR00001

PIRSF

SMART

SM00069
SM00181
SM00210
SM00282
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt