Version 5.4
Homo sapiens Gene: PRDX5
Summary
InnateDB Gene IDBG-53649.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDX5
Gene Name peroxiredoxin 5
Synonyms ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20; PRDX6; prx-V; PRXV;
Species Homo sapiens
Ensembl Gene ENSG00000126432
Encoded Proteins
IDBP-53651
peroxiredoxin 5
IDBP-53653
peroxiredoxin 5
IDBP-53655
peroxiredoxin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64318088-64321811
Strand Forward strand
Band q13.1
Transcripts
ENST00000265462 ENSP00000265462
ENST00000352435 ENSP00000335334
ENST00000347941 ENSP00000335363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 36 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001016 RNA polymerase III regulatory region DNA binding
GO:0004601 peroxidase activity
GO:0005102 receptor binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046983 protein dimerization activity
GO:0051920 peroxiredoxin activity
GO:0072541 peroxynitrite reductase activity
Biological Process
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0016480 negative regulation of transcription from RNA polymerase III promoter
GO:0032967 positive regulation of collagen biosynthetic process
GO:0034614 cellular response to reactive oxygen species
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051354 negative regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
GO:0060785 regulation of apoptosis involved in tissue homeostasis
GO:0070995 NADPH oxidation
GO:2001057 reactive nitrogen species metabolic process
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000024953
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000008648
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P30044
TrEMBL
UniProt Splice Variant
Entrez Gene 25824
UniGene
RefSeq NM_181652 NM_012094 NM_181651
HUGO HGNC:9355
OMIM 606583
CCDS CCDS8071 CCDS8069 CCDS8070
HPRD 05958
IMGT
EMBL AF110731 AF112212 AF124993 AF197952 AF231705 AF242525 AJ249483 AP001453 AP003774 BC110983 BC113723 BC113725 BC143849 BC171733 CR457203 DQ247769
GenPept AAF03750 AAF04856 AAF17200 AAF27531 AAF78899 AAF99605 AAI10984 AAI13724 AAI13726 AAI43850 AAI71733 ABB05181 CAB62210 CAG33484
RNA Seq Atlas 25824

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca