InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDX5

Summary

InnateDB Protein

IDBP-53651.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX5

Protein Name

peroxiredoxin 5

Synonyms

ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20; PRDX6; prx-V; PRXV;

Species

Homo sapiens

Ensembl Protein

ENSP00000265462

InnateDB Gene

IDBG-53649 (PRDX5)

Protein Structure

UniProt Annotation

Function

Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.

Subcellular Localization

Isoform Mitochondrial: Mitochondrion.Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10521424}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	36 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001016	RNA polymerase III regulatory region DNA binding
GO:0004601	peroxidase activity
GO:0005102	receptor binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046983	protein dimerization activity
GO:0051920	peroxiredoxin activity
GO:0072541	peroxynitrite reductase activity

Biological Process

GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0016480	negative regulation of transcription from RNA polymerase III promoter
GO:0032967	positive regulation of collagen biosynthetic process
GO:0034614	cellular response to reactive oxygen species
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051354	negative regulation of oxidoreductase activity
GO:0055114	oxidation-reduction process
GO:0060785	regulation of apoptosis involved in tissue homeostasis
GO:0070995	NADPH oxidation
GO:2001057	reactive nitrogen species metabolic process
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0031410	cytoplasmic vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome