InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GSK3A

Summary

InnateDB Gene

IDBG-53956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSK3A

Gene Name

glycogen synthase kinase 3 alpha

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105723

Encoded Proteins

IDBP-53958

glycogen synthase kinase 3 alpha

IDBP-233555

glycogen synthase kinase 3 alpha

IDBP-380987

glycogen synthase kinase 3 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26100021

Glycogen synthase kinase 3/CTNNB1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.

InnateDB Annotation from Orthologs

Summary

PMID 26100021

[Mus musculus] Glycogen synthase kinase 3/Ctnnb1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.

Entrez Gene

Summary

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer\'s disease. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:42230186-42242625

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000222330	ENSP00000222330
ENST00000398249	ENSP00000381301
ENST00000453535	ENSP00000412663
ENST00000493059

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0034236	protein kinase A catalytic subunit binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0003073	regulation of systemic arterial blood pressure
GO:0003214	cardiac left ventricle morphogenesis
GO:0005977	glycogen metabolic process
GO:0006468	protein phosphorylation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007399	nervous system development
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010905	negative regulation of UDP-glucose catabolic process
GO:0016055	Wnt signaling pathway
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032007	negative regulation of TOR signaling
GO:0032869	cellular response to insulin stimulus
GO:0036016	cellular response to interleukin-3
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0045732	positive regulation of protein catabolic process
GO:0045823	positive regulation of heart contraction
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051348	negative regulation of transferase activity
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development
GO:0071879	positive regulation of adrenergic receptor signaling pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077	negative regulation of type B pancreatic cell development
GO:2000466	negative regulation of glycogen (starch) synthase activity
GO:2000467	positive regulation of glycogen (starch) synthase activity