Homo sapiens Gene: GSK3A
Summary
InnateDB Gene IDBG-53956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSK3A
Gene Name glycogen synthase kinase 3 alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105723
Encoded Proteins
glycogen synthase kinase 3 alpha
glycogen synthase kinase 3 alpha
glycogen synthase kinase 3 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Glycogen synthase kinase 3/CTNNB1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Glycogen synthase kinase 3/Ctnnb1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
Entrez Gene
Summary This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer\'s disease. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:42230186-42242625
Strand Reverse strand
Band q13.2
Transcripts
ENST00000222330 ENSP00000222330
ENST00000398249 ENSP00000381301
ENST00000453535 ENSP00000412663
ENST00000493059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 74 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0034236 protein kinase A catalytic subunit binding
GO:0050321 tau-protein kinase activity
Biological Process
GO:0003073 regulation of systemic arterial blood pressure
GO:0003214 cardiac left ventricle morphogenesis
GO:0005977 glycogen metabolic process
GO:0006468 protein phosphorylation
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007399 nervous system development
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010905 negative regulation of UDP-glucose catabolic process
GO:0016055 Wnt signaling pathway
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032007 negative regulation of TOR signaling
GO:0032869 cellular response to insulin stimulus
GO:0036016 cellular response to interleukin-3
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0045823 positive regulation of heart contraction
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051348 negative regulation of transferase activity
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0071879 positive regulation of adrenergic receptor signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077 negative regulation of type B pancreatic cell development
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2000467 positive regulation of glycogen (starch) synthase activity
Cellular Component
GO:0005829 cytosol
GO:0030877 beta-catenin destruction complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
Wnt pathway
BCR pathway
IL3 pathway
IL5 pathway
IL-7 pathway
Leptin pathway
REACTOME
Signaling by FGFR in disease pathway
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
XBP1(S) activates chaperone genes pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
AKT phosphorylates targets in the cytosol pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
Chemokine signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Phosphoinositides and their downstream targets [Biocarta view]
PID NCI
FOXM1 transcription factor network
Cross-References
SwissProt P49840
TrEMBL A0A024R0L5 A8MT37 Q68D16
UniProt Splice Variant
Entrez Gene 2931
UniGene Hs.466828
RefSeq NM_019884
HUGO HGNC:4616
OMIM 606784
CCDS CCDS12599
HPRD
IMGT
EMBL AC006486 BC027984 BC051865 CH471126 CR749620 D63424 L40027
GenPept AAA62432 AAD11986 AAH27984 AAH51865 BAA23608 CAH18414 EAW57114 EAW57115
RNA Seq Atlas 2931