InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSK3A

Summary

InnateDB Protein

IDBP-380987.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSK3A

Protein Name

glycogen synthase kinase 3 alpha

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000412663

InnateDB Gene

IDBG-53956 (GSK3A)

Protein Structure

UniProt Annotation

Function

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. {ECO:0000269PubMed:12761548, ECO:0000269PubMed:17229088}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0034236	protein kinase A catalytic subunit binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0003073	regulation of systemic arterial blood pressure
GO:0003214	cardiac left ventricle morphogenesis
GO:0005977	glycogen metabolic process
GO:0006468	protein phosphorylation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007399	nervous system development
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010905	negative regulation of UDP-glucose catabolic process
GO:0016055	Wnt signaling pathway
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032007	negative regulation of TOR signaling
GO:0032869	cellular response to insulin stimulus
GO:0036016	cellular response to interleukin-3
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0045732	positive regulation of protein catabolic process
GO:0045823	positive regulation of heart contraction
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051348	negative regulation of transferase activity
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development
GO:0071879	positive regulation of adrenergic receptor signaling pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077	negative regulation of type B pancreatic cell development
GO:2000466	negative regulation of glycogen (starch) synthase activity
GO:2000467	positive regulation of glycogen (starch) synthase activity

Cellular Component

GO:0005829	cytosol
GO:0030877	beta-catenin destruction complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt