InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HSP90B1

Summary

InnateDB Gene

IDBG-54092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSP90B1

Gene Name

heat shock protein 90kDa beta (Grp94), member 1

Synonyms

ECGP; GP96; GRP94; HEL-S-125m; HEL35; TRA1

Species

Homo sapiens

Ensembl Gene

ENSG00000166598

Encoded Proteins

IDBP-54094

heat shock protein 90kDa beta (Grp94), member 1

IDBP-599890

heat shock protein 90kDa beta (Grp94), member 1

IDBP-600295

heat shock protein 90kDa beta (Grp94), member 1

IDBP-585319

heat shock protein 90kDa beta (Grp94), member 1

IDBP-811597

heat shock protein 90kDa beta (Grp94), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16754684

HSP90B1 amplifies innate and adaptive immune responses via interaction with TLR2 and TLR4 ligands.

PMID 11584270

Absence of HSP90B1 results in a defect in the formation of some cell surface receptors including Toll-like receptors (TLRs) which, as a result, are retained intracellularly.

PMID 19965672

HSP90B1 is an endoplasmic reticulum master chaperone for multiple TLRs and is also essential for expression of multiple hematopoietic system-specific integrins.

PMID 20351288

HSP90B1, an endoplasmic reticulum chaperone, is required in vesicular stomatitis virus (VSV) infection and in innate immunity via Toll-like receptors (TLRs). TLR-mediated immunity maintains the broad host range of the envelope glycoprotein of VSV (VSV-G) by positively selecting for the ubiquitous expression of HSP90B1.

PMID 20865800

HSP90B1 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in a manner that is dependent on another endoplasmic reticulum (ER) luminal protein, CNPY3.

PMID 22109526

HSP90B1 on the surface of polymorphonuclear leukocytes (PMNs) serves as a receptor for Escherichia coli K1 (EC-K1) entry into the cell. EC-K1 exploits surface-expressed HSP90B1 in PMNs to prevent oxidative burst for the onset of neonatal meningitis. (Demonstrated in mice)

PMID 22223641

HSP90B1 is an essential endoplasmic reticulum chaperone protein for Toll-like receptors (TLR) and integrins. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22109526

[Mus musculus] Hsp90b1 on the surface of polymorphonuclear leukocytes (PMNs) serves as a receptor for Escherichia coli K1 (EC-K1) entry. EC-K1 exploits surface-expressed Hsp90b1 in PMNs to prevent oxidative burst for the onset of neonatal meningitis.

PMID 22223641

[Mus musculus] Hsp90b1 is an essential endoplasmic reticulum chaperone protein for Toll-like receptors and integrins.

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5\' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:103930107-103953645

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000299767	ENSP00000299767
ENST00000549334	ENSP00000446748
ENST00000548622
ENST00000540297	ENSP00000446266
ENST00000548462
ENST00000550479
ENST00000551983
ENST00000552051
ENST00000550595	ENSP00000450215
ENST00000614327	ENSP00000477660

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	114 [view]
Protein-Protein	107 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019903	protein phosphatase binding
GO:0046790	virion binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0002224	toll-like receptor signaling pathway
GO:0006457	protein folding
GO:0006950	response to stress
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0015031	protein transport
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031247	actin rod assembly
GO:0043066	negative regulation of apoptotic process
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051208	sequestering of calcium ion
GO:0071318	cellular response to ATP

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0042470	melanosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen