InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSP90B1

Summary

InnateDB Protein

IDBP-54094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSP90B1

Protein Name

heat shock protein 90kDa beta (Grp94), member 1

Synonyms

ECGP; GP96; GRP94; HEL-S-125m; HEL35; TRA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000299767

InnateDB Gene

IDBG-54092 (HSP90B1)

Protein Structure

UniProt Annotation

Function

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. {ECO:0000250, ECO:0000269PubMed:18264092}.

Subcellular Localization

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	114 [view]
Protein-Protein	107 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019903	protein phosphatase binding
GO:0046790	virion binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0002224	toll-like receptor signaling pathway
GO:0006457	protein folding
GO:0006950	response to stress
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0015031	protein transport
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031247	actin rod assembly
GO:0043066	negative regulation of apoptotic process
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051208	sequestering of calcium ion
GO:0071318	cellular response to ATP

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0042470	melanosome
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen

Protein Structure and Domains

PDB ID

InterPro

IPR001404 Heat shock protein Hsp90 family
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR020575 Heat shock protein Hsp90, N-terminal

PFAM

PF00183
PF02518
PF13581

PRINTS

PR00775

PIRSF

PIRSF002583

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References