InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFYB

Summary

InnateDB Gene

IDBG-54317.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFYB

Gene Name

nuclear transcription factor Y, beta

Synonyms

CBF-A; CBF-B; HAP3; NF-YB

Species

Homo sapiens

Ensembl Gene

ENSG00000120837

Encoded Proteins

IDBP-54319

nuclear transcription factor Y, beta

IDBP-598665

nuclear transcription factor Y, beta

IDBP-589366

nuclear transcription factor Y, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:104117077-104138289

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000240055	ENSP00000240055
ENST00000551727	ENSP00000447486
ENST00000550189
ENST00000551446	ENSP00000448250
ENST00000550881

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	30 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated