Homo sapiens Gene: NFYB
Summary
InnateDB Gene IDBG-54317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFYB
Gene Name nuclear transcription factor Y, beta
Synonyms CBF-A; CBF-B; HAP3; NF-YB;
Species Homo sapiens
Ensembl Gene ENSG00000120837
Encoded Proteins
nuclear transcription factor Y, beta
nuclear transcription factor Y, beta
nuclear transcription factor Y, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:104117077-104138289
Strand Reverse strand
Band q23.3
Transcripts
ENST00000240055 ENSP00000240055
ENST00000551727 ENSP00000447486
ENST00000550189
ENST00000551446 ENSP00000448250
ENST00000550881
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 30 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0070491 repressing transcription factor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016602 CCAAT-binding factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Unfolded Protein Response (UPR) pathway
ATF4 activates genes pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
ATF6-alpha activates chaperone genes pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
ATF6-alpha activates chaperones pathway
KEGG
Antigen processing and presentation pathway
INOH
PID BIOCARTA
Overview of telomerase rna component gene hterc transcriptional regulation [Biocarta view]
PID NCI
Direct p53 effectors
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597005 Hs.600343 Hs.712952 Hs.84928
RefSeq NM_006166
HUGO
OMIM
CCDS CCDS9098
HPRD 01794
IMGT
EMBL
GenPept
RNA Seq Atlas