InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFYB

Summary

InnateDB Protein

IDBP-598665.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFYB

Protein Name

nuclear transcription factor Y, beta

Synonyms

CBF-A; CBF-B; HAP3; NF-YB;

Species

Homo sapiens

Ensembl Protein

ENSP00000447486

InnateDB Gene

IDBG-54317 (NFYB)

Protein Structure

UniProt Annotation

Function

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	30 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process