Homo sapiens Gene: MTAP
Summary
InnateDB Gene IDBG-54400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTAP
Gene Name methylthioadenosine phosphorylase
Synonyms BDMF; c86fus; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP;
Species Homo sapiens
Ensembl Gene ENSG00000099810
Encoded Proteins
methylthioadenosine phosphorylase
methylthioadenosine phosphorylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21802543-21937651
Strand Forward strand
Band p21.3
Transcripts
ENST00000380172 ENSP00000369519
ENST00000419385 ENSP00000393507
ENST00000427788
ENST00000460874 ENSP00000461932
ENST00000484957
ENST00000580900 ENSP00000463424
ENST00000580675
ENST00000580718 ENSP00000464616
ENST00000579422
ENST00000577563 ENSP00000462082
ENST00000581962
ENST00000584988
ENST00000616982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 22 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004645 phosphorylase activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006166 purine ribonucleoside salvage
GO:0006595 polyamine metabolic process
GO:0009116 nucleoside metabolic process
GO:0019509 L-methionine biosynthetic process from methylthioadenosine
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Methionine salvage pathway pathway
Metabolism of polyamines pathway
Sulfur amino acid metabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Cysteine and methionine metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q13126
TrEMBL
UniProt Splice Variant
Entrez Gene 4507
UniGene Hs.193268
RefSeq NM_002451
HUGO HGNC:7413
OMIM 156540
CCDS CCDS6509
HPRD 01134
IMGT
EMBL AL359922 AY712791 BC026106 CH471071 HE654772 HE654773 HE654774 HE654775 HE654776 HE654777 L40432 L42627 L42628 L42629 L42630 L42631 L42632 L42633 L42634 U22233
GenPept AAA81646 AAG38871 AAH26106 AAR24607 AAU04442 CAI16481 CCF77345 CCF77346 CCF77347 CCF77348 CCF77349 CCF77350 EAW58606
RNA Seq Atlas 4507