InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHST11

Summary

InnateDB Gene

IDBG-54479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST11

Gene Name

carbohydrate (chondroitin 4) sulfotransferase 11

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000171310

Encoded Proteins

IDBP-54481

carbohydrate (chondroitin 4) sulfotransferase 11

IDBP-596251

carbohydrate (chondroitin 4) sulfotransferase 11

IDBP-590150

carbohydrate (chondroitin 4) sulfotransferase 11

IDBP-588256

carbohydrate (chondroitin 4) sulfotransferase 11

IDBP-591909

carbohydrate (chondroitin 4) sulfotransferase 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:104455295-104762014

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000303694	ENSP00000305725
ENST00000550711
ENST00000547956	ENSP00000449093
ENST00000549260	ENSP00000450004
ENST00000546689	ENSP00000448678
ENST00000549016	ENSP00000449095

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0047756	chondroitin 4-sulfotransferase activity
GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Biological Process

GO:0002063	chondrocyte development
GO:0005975	carbohydrate metabolic process
GO:0007585	respiratory gaseous exchange
GO:0009791	post-embryonic development
GO:0016051	carbohydrate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030326	embryonic limb morphogenesis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0033037	polysaccharide localization
GO:0036342	post-anal tail morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0048589	developmental growth
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0051216	cartilage development