InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST11

Summary

InnateDB Protein

IDBP-54481.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST11

Protein Name

carbohydrate (chondroitin 4) sulfotransferase 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000305725

InnateDB Gene

IDBG-54479 (CHST11)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH. {ECO:0000269PubMed:15273723}.

Tissue Specificity

Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung and placenta. {ECO:0000269PubMed:10781601, ECO:0000269PubMed:11056388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0047756	chondroitin 4-sulfotransferase activity
GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Biological Process

GO:0002063	chondrocyte development
GO:0005975	carbohydrate metabolic process
GO:0007585	respiratory gaseous exchange
GO:0009791	post-embryonic development
GO:0016051	carbohydrate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030326	embryonic limb morphogenesis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0033037	polysaccharide localization
GO:0036342	post-anal tail morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0048589	developmental growth
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0051216	cartilage development