Version 5.4
Homo sapiens Gene: G3BP1
Summary
InnateDB Gene IDBG-54619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G3BP1
Gene Name GTPase activating protein (SH3 domain) binding protein 1
Synonyms G3BP; HDH-VIII
Species Homo sapiens
Ensembl Gene ENSG00000145907
Encoded Proteins
IDBP-54621
GTPase activating protein (SH3 domain) binding protein 1
IDBP-242220
GTPase activating protein (SH3 domain) binding protein 1
IDBP-478944
GTPase activating protein (SH3 domain) binding protein 1
IDBP-481209
GTPase activating protein (SH3 domain) binding protein 1
IDBP-483031
GTPase activating protein (SH3 domain) binding protein 1
IDBP-485171
GTPase activating protein (SH3 domain) binding protein 1
IDBP-474963
GTPase activating protein (SH3 domain) binding protein 1
IDBP-474522
GTPase activating protein (SH3 domain) binding protein 1
IDBP-482325
GTPase activating protein (SH3 domain) binding protein 1
IDBP-478789
GTPase activating protein (SH3 domain) binding protein 1
IDBP-479456
GTPase activating protein (SH3 domain) binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25520508
EIF2AK2 (PKR) is recruited to stress granules by G3BP1 to promote innate immune responses at both transcriptional and translational levels.
PMID 25784705
The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.
Entrez Gene
Summary This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3\'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:151771045-151812785
Strand Forward strand
Band q33.1
Transcripts
ENST00000356245 ENSP00000348578
ENST00000394123 ENSP00000377681
ENST00000523519 ENSP00000430738
ENST00000520578 ENSP00000429920
ENST00000522761 ENSP00000430480
ENST00000518726
ENST00000519832
ENST00000520177 ENSP00000427810
ENST00000507878 ENSP00000429250
ENST00000517947 ENSP00000430045
ENST00000522367 ENSP00000428926
ENST00000520006 ENSP00000428469
ENST00000522666 ENSP00000429316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 116 [view]
Protein-Protein 114 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003729 mRNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0007265 Ras protein signal transduction
GO:0032508 DNA duplex unwinding
GO:0045087 innate immune response (InnateDB)
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010494 cytoplasmic stress granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018583
View Gene Order
ENSBTAG00000020309
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.30980 Hs.3353 Hs.587054 Hs.595645 Hs.600794 Hs.660566 Hs.684144 Hs.699092 Hs.707858
RefSeq NM_005754 NM_198395 XM_006714749 XM_006714750
HUGO
OMIM
CCDS CCDS4319
HPRD 06569
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca