Homo sapiens Gene: NMUR2
Summary
InnateDB Gene IDBG-54702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NMUR2
Gene Name neuromedin U receptor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132911
Encoded Proteins
neuromedin U receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:152391532-152433368
Strand Reverse strand
Band q33.1
Transcripts
ENST00000255262 ENSP00000255262
ENST00000518933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001607 neuromedin U receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005525 GTP binding
GO:0008188 neuropeptide receptor activity
GO:0042924 neuromedin U binding
Biological Process
GO:0002023 reduction of food intake in response to dietary excess
GO:0006816 calcium ion transport
GO:0006821 chloride transport
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007417 central nervous system development
GO:0007625 grooming behavior
GO:0007631 feeding behavior
GO:0019722 calcium-mediated signaling
GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling
GO:0048016 inositol phosphate-mediated signaling
GO:0048265 response to pain
GO:0050482 arachidonic acid secretion
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731911
RefSeq NM_020167
HUGO
OMIM
CCDS CCDS4321
HPRD 12003
IMGT
EMBL
GenPept
RNA Seq Atlas