InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NMUR2

Summary

InnateDB Gene

IDBG-54702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMUR2

Gene Name

neuromedin U receptor 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000132911

Encoded Proteins

IDBP-54704

neuromedin U receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:152391532-152433368

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000255262	ENSP00000255262
ENST00000518933

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001607	neuromedin U receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005229	intracellular calcium activated chloride channel activity
GO:0005525	GTP binding
GO:0008188	neuropeptide receptor activity
GO:0042924	neuromedin U binding

Biological Process

GO:0002023	reduction of food intake in response to dietary excess
GO:0006816	calcium ion transport
GO:0006821	chloride transport
GO:0006940	regulation of smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007417	central nervous system development
GO:0007625	grooming behavior
GO:0007631	feeding behavior
GO:0019722	calcium-mediated signaling
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling
GO:0048016	inositol phosphate-mediated signaling
GO:0048265	response to pain
GO:0050482	arachidonic acid secretion
GO:1902476	chloride transmembrane transport