Version 5.4
Homo sapiens Gene: PLXNA1
Summary
InnateDB Gene IDBG-54782.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNA1
Gene Name plexin A1
Synonyms NOV; NOVP; PLEXIN-A1; PLXN1
Species Homo sapiens
Ensembl Gene ENSG00000114554
Encoded Proteins
IDBP-243674
plexin A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:126988594-127037392
Strand Forward strand
Band q21.3
Transcripts
ENST00000393409 ENSP00000377061
ENST00000503234
ENST00000503363
ENST00000505278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0014910 regulation of smooth muscle cell migration
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0002116 semaphorin receptor complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030084
View Gene Order
ENSBTAG00000009159
Not yet available
Pathways
NETPATH
REACTOME
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19200
Other semaphorin interactions pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.432329 Hs.623489
RefSeq NM_032242 XM_006713663
HUGO
OMIM
CCDS CCDS33847
HPRD 11868
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca