InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLXNA1

Summary

InnateDB Protein

IDBP-243674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLXNA1

Protein Name

plexin A1

Synonyms

NOV; NOVP; PLEXIN-A1; PLXN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000377061

InnateDB Gene

IDBG-54782 (PLXNA1)

Protein Structure

UniProt Annotation

Function

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in fetal brain, lung, liver and kidney. {ECO:0000269PubMed:8570614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0014910	regulation of smooth muscle cell migration
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0002116	semaphorin receptor complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UIW2