InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP3K14

Summary

InnateDB Gene

IDBG-54829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K14

Gene Name

mitogen-activated protein kinase kinase kinase 14

Synonyms

FTDCR1B; HS; HSNIK; NIK

Species

Homo sapiens

Ensembl Gene

ENSG00000006062

Encoded Proteins

IDBP-812405

mitogen-activated protein kinase kinase kinase 14

IDBP-812409

mitogen-activated protein kinase kinase kinase 14

IDBP-812407

mitogen-activated protein kinase kinase kinase 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18550535

MAP3K14 associates with DDX58 (RIG-I) and its downstream adaptor, mitochondrial antiviral signaling (MAVS) and the MAP3K14-DDX58 signalling pathway induces RELA release from NFKB2 complexes in response to respiratory syncytial virus (RSV) infection.

PMID 16552041

MAP3K14 binds to NOD2 and mediates induction of specific changes induced by NOD2 activator muramyl dipeptide (MDP) and this occurs in settings where both the NOD2 and TLR4 pathways are activated by their respective agonists.

Entrez Gene

Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:45263121-45317040

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000344686	ENSP00000478552
ENST00000376926	ENSP00000482657
ENST00000592267
ENST00000586644
ENST00000617331	ENSP00000480974

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.

Experimentally validated
Total	162 [view]
Protein-Protein	162 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0031295	T cell costimulation
GO:0038061	NIK/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0071260	cellular response to mechanical stimulus