InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K14

Summary

InnateDB Protein

IDBP-812405.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K14

Protein Name

mitogen-activated protein kinase kinase kinase 14

Synonyms

FTDCR1B; HS; HSNIK; NIK;

Species

Homo sapiens

Ensembl Protein

ENSP00000478552

InnateDB Gene

IDBG-54829 (MAP3K14)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.

Experimentally validated
Total	162 [view]
Protein-Protein	162 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0031295	T cell costimulation
GO:0038061	NIK/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017425 Mitogen-activated protein (MAP) kinase kinase kinase 14
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF038175

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References