Version 5.4
Homo sapiens Gene: AAK1
Summary
InnateDB Gene IDBG-54929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AAK1
Gene Name AP2 associated kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115977
Encoded Proteins
IDBP-295667
AP2 associated kinase 1
IDBP-295668
AP2 associated kinase 1
IDBP-295664
AP2 associated kinase 1
IDBP-811193
AP2 associated kinase 1
IDBP-811205
AP2 associated kinase 1
IDBP-811217
AP2 associated kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:69457995-69674349
Strand Reverse strand
Band p13.3
Transcripts
ENST00000409068 ENSP00000386342
ENST00000409085 ENSP00000386456
ENST00000406297 ENSP00000385181
ENST00000489327
ENST00000470281
ENST00000495836
ENST00000495239
ENST00000471775
ENST00000461002
ENST00000492192
ENST00000606389 ENSP00000485350
ENST00000623317 ENSP00000485296
ENST00000624900 ENSP00000485409
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035612 AP-2 adaptor complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006897 endocytosis
GO:0032880 regulation of protein localization
GO:0045747 positive regulation of Notch signaling pathway
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:2000369 regulation of clathrin-mediated endocytosis
Cellular Component
GO:0005905 coated pit
GO:0019897 extrinsic component of plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0031252 cell leading edge
GO:0043195 terminal bouton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057230
View Gene Order
ENSBTAG00000009343
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.468878
RefSeq NM_014911
HUGO
OMIM
CCDS CCDS1893
HPRD 10620
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca