Version 5.4
Bos taurus Gene: AAK1
Summary
InnateDB Gene IDBG-635824.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AAK1
Gene Name AP2-associated protein kinase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009343
Encoded Proteins
IDBP-687743
AP2 associated kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115977:
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67812869-67964370
Strand Reverse strand
Band
Transcripts
ENSBTAT00000012302 ENSBTAP00000012302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035612 AP-2 adaptor complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006897 endocytosis
GO:0016310 phosphorylation
GO:0032880 regulation of protein localization
GO:0045747 positive regulation of Notch signaling pathway
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:2000369 regulation of clathrin-mediated endocytosis
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0031252 cell leading edge
GO:0043195 terminal bouton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115977
View Gene Order
ENSMUSG00000057230
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.111101 Bt.91311
RefSeq XM_002691441 XM_005193927 XM_005212906 XM_611658
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca