InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TIA1

Summary

InnateDB Gene

IDBG-55200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIA1

Gene Name

TIA1 cytotoxic granule-associated RNA binding protein

Synonyms

TIA-1; WDM

Species

Homo sapiens

Ensembl Gene

ENSG00000116001

Encoded Proteins

IDBP-55202

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-55204

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-378555

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-378557

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-378561

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-378562

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-378564

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-478523

TIA1 cytotoxic granule-associated RNA binding protein

IDBP-477767

TIA1 cytotoxic granule-associated RNA binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:70209444-70248660

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000282574	ENSP00000282574
ENST00000361692	ENSP00000354838
ENST00000415783	ENSP00000404023
ENST00000433529	ENSP00000401371
ENST00000445587	ENSP00000399567
ENST00000454815	ENSP00000402263
ENST00000416149	ENSP00000413751
ENST00000486392
ENST00000495774
ENST00000468787
ENST00000482876
ENST00000497672
ENST00000477415
ENST00000496096
ENST00000484065
ENST00000474699
ENST00000474809	ENSP00000430969
ENST00000477044	ENSP00000427794
ENST00000496452
ENST00000481650

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	17 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0017091	AU-rich element binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0017148	negative regulation of translation
GO:0042036	negative regulation of cytokine biosynthetic process
GO:0048024	regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0097165	nuclear stress granule

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000071337

View Gene Order

ENSBTAG00000019182

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E5RG67

UniProt Splice Variant

Entrez Gene

7072

UniGene

Hs.413123 Hs.697347 Hs.743719

RefSeq

NM_022037 NM_022173 XM_005264524 XM_005264525 XM_005264526 XM_005264527 XM_005264528

HUGO

HGNC:11802

OMIM

603518

CCDS

CCDS1900 CCDS1901

HPRD

04626

IMGT

EMBL

AC016700

GenPept

RNA Seq Atlas

7072