Homo sapiens Gene: TIA1
Summary
InnateDB Gene IDBG-55200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIA1
Gene Name TIA1 cytotoxic granule-associated RNA binding protein
Synonyms TIA-1; WDM;
Species Homo sapiens
Ensembl Gene ENSG00000116001
Encoded Proteins
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
TIA1 cytotoxic granule-associated RNA binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70209444-70248660
Strand Reverse strand
Band p13.3
Transcripts
ENST00000282574 ENSP00000282574
ENST00000361692 ENSP00000354838
ENST00000415783 ENSP00000404023
ENST00000433529 ENSP00000401371
ENST00000445587 ENSP00000399567
ENST00000454815 ENSP00000402263
ENST00000416149 ENSP00000413751
ENST00000486392
ENST00000495774
ENST00000468787
ENST00000482876
ENST00000497672
ENST00000477415
ENST00000496096
ENST00000484065
ENST00000474699
ENST00000474809 ENSP00000430969
ENST00000477044 ENSP00000427794
ENST00000496452
ENST00000481650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 30 [view]
Protein-DNA 2 [view]
Protein-RNA 17 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008143 poly(A) binding
GO:0017091 AU-rich element binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006915 apoptotic process
GO:0017148 negative regulation of translation
GO:0042036 negative regulation of cytokine biosynthetic process
GO:0048024 regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0097165 nuclear stress granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
West nile virus [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL E5RGV5
UniProt Splice Variant
Entrez Gene 7072
UniGene Hs.413123 Hs.697347 Hs.743719
RefSeq NM_022173 NM_022037 XM_005264528 XM_005264525 XM_005264524 XM_005264527 XM_005264526
HUGO HGNC:11802
OMIM 603518
CCDS CCDS1901 CCDS1900
HPRD 04626
IMGT
EMBL AC016700
GenPept
RNA Seq Atlas 7072