Homo sapiens Gene: LPCAT4
Summary
InnateDB Gene IDBG-5526.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPCAT4
Gene Name lysophosphatidylcholine acyltransferase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176454
Encoded Proteins
lysophosphatidylcholine acyltransferase 4
lysophosphatidylcholine acyltransferase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:34358618-34367278
Strand Reverse strand
Band q14
Transcripts
ENST00000314891 ENSP00000317300
ENST00000567507 ENSP00000454422
ENST00000562431
ENST00000562404
ENST00000563748
ENST00000566581
ENST00000569804
ENST00000563240
ENST00000623384
ENST00000617710 ENSP00000478003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0016746 transferase activity, transferring acyl groups
GO:0047166 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity
GO:0071617 lysophospholipid acyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008152 metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Acyl chain remodelling of PS pathway
Metabolism of lipids and lipoproteins pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
Triglyceride Biosynthesis pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.352614 Hs.679237
RefSeq NM_153613
HUGO
OMIM
CCDS CCDS32191
HPRD 08315
IMGT
EMBL
GenPept
RNA Seq Atlas