InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPCAT4

Summary

InnateDB Protein

IDBP-5530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPCAT4

Protein Name

lysophosphatidylcholine acyltransferase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317300

InnateDB Gene

IDBG-5526 (LPCAT4)

Protein Structure

UniProt Annotation

Function

Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. {ECO:0000269PubMed:18458083}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16243729, ECO:0000269PubMed:18458083}; Multi- pass membrane protein {ECO:0000269PubMed:16243729, ECO:0000269PubMed:18458083}.

Disease Associations

Tissue Specificity

Widely expressed with predominant level in brain. {ECO:0000269PubMed:16243729, ECO:0000269PubMed:18458083}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0016746	transferase activity, transferring acyl groups
GO:0047166	1-alkenylglycerophosphoethanolamine O-acyltransferase activity
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity
GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity
GO:0071617	lysophospholipid acyltransferase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process