Version 5.4
Homo sapiens Gene: PCYOX1
Summary
InnateDB Gene IDBG-55265.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCYOX1
Gene Name prenylcysteine oxidase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116005
Encoded Proteins
IDBP-55267
prenylcysteine oxidase 1
IDBP-378575
prenylcysteine oxidase 1
IDBP-378577
prenylcysteine oxidase 1
IDBP-378590
prenylcysteine oxidase 1
IDBP-378594
prenylcysteine oxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70257386-70281191
Strand Forward strand
Band p13.3
Transcripts
ENST00000264441 ENSP00000264441
ENST00000422380 ENSP00000404327
ENST00000414812 ENSP00000413178
ENST00000433351 ENSP00000387654
ENST00000451279 ENSP00000408751
ENST00000480949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001735 prenylcysteine oxidase activity
GO:0008555 chloride-transporting ATPase activity
GO:0016491 oxidoreductase activity
GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
Biological Process
GO:0006821 chloride transport
GO:0030327 prenylated protein catabolic process
GO:0030328 prenylcysteine catabolic process
GO:0030329 prenylcysteine metabolic process
GO:0055114 oxidation-reduction process
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0034361 very-low-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029998
View Gene Order
ENSBTAG00000002783
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9UHG3
TrEMBL B7Z3Y2 B7Z8A2 B7Z9P8 C9JGT6 C9JM55 C9K055 F8W8W4 Q53ST0 Q584P1
UniProt Splice Variant
Entrez Gene 51449
UniGene Hs.567502 Hs.606863 Hs.639218
RefSeq NM_016297
HUGO HGNC:20588
OMIM 610995
CCDS CCDS1902
HPRD
IMGT
EMBL AB020715 AC016700 AC079338 AF181490 AK296478 AK303043 AK314453 AK316013 AY359063 BC007029 BC033815 BC051891 CH471053
GenPept AAF16937 AAH07029 AAH33815 AAH51891 AAQ89422 AAX81995 AAX93194 BAA74931 BAG37061 BAH12368 BAH13888 BAH14384 EAW99819
RNA Seq Atlas 51449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca