Homo sapiens Gene: KCNN4
Summary
InnateDB Gene IDBG-55572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNN4
Gene Name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Synonyms hIKCa1; hKCa4; hSK4; IK1; IKCA1; KCa3.1; KCA4; SK4;
Species Homo sapiens
Ensembl Gene ENSG00000104783
Encoded Proteins
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:43766533-43781257
Strand Reverse strand
Band q13.31
Transcripts
ENST00000262888 ENSP00000262888
ENST00000600909 ENSP00000470339
ENST00000601549
ENST00000600408 ENSP00000472510
ENST00000598836 ENSP00000471900
ENST00000599107
ENST00000597184
ENST00000599720 ENSP00000472513
ENST00000615047 ENSP00000485014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015269 calcium-activated potassium channel activity
GO:0016286 small conductance calcium-activated potassium channel activity
GO:0019903 protein phosphatase binding
GO:0022894 Intermediate conductance calcium-activated potassium channel activity
Biological Process
GO:0002376 immune system process
GO:0006813 potassium ion transport
GO:0006816 calcium ion transport
GO:0006820 anion transport
GO:0006884 cell volume homeostasis
GO:0006952 defense response
GO:0007268 synaptic transmission
GO:0030322 stabilization of membrane potential
GO:0045332 phospholipid translocation
GO:0046541 saliva secretion
GO:0050714 positive regulation of protein secretion
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0071435 potassium ion export
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0043025 neuronal cell body
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ca2+ activated K+ channels pathway
Neuronal System pathway
Potassium Channels pathway
KEGG
Salivary secretion pathway
Protein digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL M0QZ70
UniProt Splice Variant
Entrez Gene 3783
UniGene Hs.10082
RefSeq NM_002250 XM_005258883
HUGO HGNC:6293
OMIM 602754
CCDS CCDS12630
HPRD 04130
IMGT
EMBL AC115522
GenPept
RNA Seq Atlas 3783