InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNN4

Summary

InnateDB Gene

IDBG-55572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNN4

Gene Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Synonyms

hIKCa1; hKCa4; hSK4; IK1; IKCA1; KCa3.1; KCA4; SK4

Species

Homo sapiens

Ensembl Gene

ENSG00000104783

Encoded Proteins

IDBP-55574

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

IDBP-760362

IDBP-761551

IDBP-759910

IDBP-762039

IDBP-811009

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:43766533-43781257

Strand

Reverse strand

Band

q13.31

Transcripts

ENST00000262888	ENSP00000262888
ENST00000600909	ENSP00000470339
ENST00000601549
ENST00000600408	ENSP00000472510
ENST00000598836	ENSP00000471900
ENST00000599107
ENST00000597184
ENST00000599720	ENSP00000472513
ENST00000615047	ENSP00000485014

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015269	calcium-activated potassium channel activity
GO:0016286	small conductance calcium-activated potassium channel activity
GO:0019903	protein phosphatase binding
GO:0022894	Intermediate conductance calcium-activated potassium channel activity

Biological Process

GO:0002376	immune system process
GO:0006813	potassium ion transport
GO:0006816	calcium ion transport
GO:0006820	anion transport
GO:0006884	cell volume homeostasis
GO:0006952	defense response
GO:0007268	synaptic transmission
GO:0030322	stabilization of membrane potential
GO:0045332	phospholipid translocation
GO:0046541	saliva secretion
GO:0050714	positive regulation of protein secretion
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0043025	neuronal cell body
GO:0045121	membrane raft

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000054342

View Gene Order

ENSBTAG00000004588

Not yet available

Pathways

NETPATH

REACTOME

REACT_75896

Ca2+ activated K+ channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

hsa04970

Salivary secretion pathway

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

M0QZ70

UniProt Splice Variant

Entrez Gene

3783

UniGene

Hs.10082

RefSeq

NM_002250 XM_005258883

HUGO

HGNC:6293

OMIM

602754

CCDS

CCDS12630

HPRD

04130

IMGT

EMBL

AC115522

GenPept

RNA Seq Atlas

3783