Homo sapiens Gene: CD207
Summary
InnateDB Gene IDBG-55659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD207
Gene Name CD207 molecule, langerin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116031
Encoded Proteins
CD207 molecule, langerin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70830214-70835822
Strand Reverse strand
Band p13.3
Transcripts
ENST00000410009 ENSP00000386378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0051607 defense response to virus
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030139 endocytic vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.199731
RefSeq NM_015717
HUGO
OMIM
CCDS CCDS74520
HPRD 07278
IMGT
EMBL
GenPept
RNA Seq Atlas