Version 5.4
Homo sapiens Gene: VAX2
Summary
InnateDB Gene IDBG-55700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAX2
Gene Name ventral anterior homeobox 2
Synonyms DRES93
Species Homo sapiens
Ensembl Gene ENSG00000116035
Encoded Proteins
IDBP-55702
ventral anterior homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70900590-70933446
Strand Forward strand
Band p13.3
Transcripts
ENST00000234392 ENSP00000234392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0031490 chromatin DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007398 ectoderm development
GO:0007409 axonogenesis
GO:0007601 visual perception
GO:0009950 dorsal/ventral axis specification
GO:0016055 Wnt signaling pathway
GO:0030900 forebrain development
GO:0043010 camera-type eye development
GO:0048048 embryonic eye morphogenesis
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034777
View Gene Order
ENSBTAG00000010605
Not yet available
Cross-References
SwissProt Q9UIW0
TrEMBL F1T0K5
UniProt Splice Variant
Entrez Gene 25806
UniGene Hs.249170
RefSeq NM_012476
HUGO HGNC:12661
OMIM 604295
CCDS CCDS1911
HPRD
IMGT
EMBL AB593145 BC006336 BT007035 CH471053 Y17791
GenPept AAH06336 AAP35683 BAJ84079 CAB56166 EAW99792
RNA Seq Atlas 25806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca