Version 5.4
Homo sapiens Gene: DYNLT3
Summary
InnateDB Gene IDBG-55905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYNLT3
Gene Name dynein, light chain, Tctex-type 3
Synonyms RP3; TCTE1L; TCTEX1L
Species Homo sapiens
Ensembl Gene ENSG00000165169
Encoded Proteins
IDBP-55907
dynein, light chain, Tctex-type 3
IDBP-55909
dynein, light chain, Tctex-type 3
IDBP-366931
dynein, light chain, Tctex-type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:37836757-37847637
Strand Reverse strand
Band p11.4
Transcripts
ENST00000378581 ENSP00000367844
ENST00000378578 ENSP00000367841
ENST00000432389 ENSP00000402695
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006810 transport
GO:0007067 mitotic nuclear division
GO:0007346 regulation of mitotic cell cycle
GO:0008152 metabolic process
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031176
View Gene Order
ENSBTAG00000038156
Not yet available
Cross-References
SwissProt P51808
TrEMBL A6NGJ0 F2Z328
UniProt Splice Variant
Entrez Gene 6990
UniGene Hs.446392 Hs.604656 Hs.690541
RefSeq NM_006520
HUGO HGNC:11694
OMIM 300302
CCDS CCDS14243
HPRD
IMGT
EMBL AK311851 AL121578 BC000968 CH471141 CR450320 CR542213 U02556
GenPept AAA57444 AAH00968 BAG34793 CAG29316 CAG47009 EAW59452
RNA Seq Atlas 6990

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca