InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYNLT3

Summary

InnateDB Protein

IDBP-55909.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNLT3

Protein Name

dynein, light chain, Tctex-type 3

Synonyms

RP3; TCTE1L; TCTEX1L;

Species

Homo sapiens

Ensembl Protein

ENSP00000367841

InnateDB Gene

IDBG-55905 (DYNLT3)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006810	transport
GO:0007067	mitotic nuclear division
GO:0007346	regulation of mitotic cell cycle
GO:0008152	metabolic process

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule