Version 5.4
Homo sapiens Gene: TOPORS
Summary
InnateDB Gene IDBG-55971.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOPORS
Gene Name topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Synonyms LUN; P53BP3; RP31; TP53BPL
Species Homo sapiens
Ensembl Gene ENSG00000197579
Encoded Proteins
IDBP-55973
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
IDBP-55975
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:32540544-32552553
Strand Reverse strand
Band p21.1
Transcripts
ENST00000360538 ENSP00000353735
ENST00000379858 ENSP00000369187
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003823 antigen binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019789 SUMO ligase activity
GO:0044547 DNA topoisomerase binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010842 retina layer formation
GO:0016925 protein sumoylation
GO:0034504 protein localization to nucleus
GO:0035845 photoreceptor cell outer segment organization
GO:0042127 regulation of cell proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046548 retinal rod cell development
GO:0046549 retinal cone cell development
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051457 maintenance of protein location in nucleus
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000922 spindle pole
GO:0000930 gamma-tubulin complex
GO:0005634 nucleus
GO:0005814 centriole
GO:0005868 cytoplasmic dynein complex
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0030496 midbody
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036822
View Gene Order
ENSBTAG00000005905
Not yet available
Cross-References
SwissProt Q9NS56
TrEMBL
UniProt Splice Variant
Entrez Gene 10210
UniGene Hs.589962 Hs.608203
RefSeq NM_001195622 NM_005802
HUGO HGNC:21653
OMIM 609507
CCDS CCDS56566 CCDS6527
HPRD
IMGT
EMBL AB045732 AB045733 AF098300 AL353671 BC060884 U82939
GenPept AAC98530 AAD23379 AAH60884 BAB03714 BAB03715 CAH71253 CAH71254
RNA Seq Atlas 10210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca