Version 5.4
Homo sapiens Gene: FOXF2
Summary
InnateDB Gene IDBG-56008.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXF2
Gene Name forkhead box F2
Synonyms FKHL6; FREAC-2; FREAC2
Species Homo sapiens
Ensembl Gene ENSG00000137273
Encoded Proteins
IDBP-56010
forkhead box F2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:1389834-1395597
Strand Forward strand
Band p25.3
Transcripts
ENST00000259806 ENSP00000259806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001837 epithelial to mesenchymal transition
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030198 extracellular matrix organization
GO:0042249 establishment of planar polarity of embryonic epithelium
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048566 embryonic digestive tract development
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048806 genitalia development
GO:0060021 palate development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038402
View Gene Order
ENSBTAG00000026896
Not yet available
Cross-References
SwissProt Q12947
TrEMBL
UniProt Splice Variant
Entrez Gene 2295
UniGene Hs.484423
RefSeq NM_001452
HUGO HGNC:3810
OMIM 603250
CCDS CCDS4472
HPRD
IMGT
EMBL AF084938 AF084939 AL034346 CH471087 U13220
GenPept AAC32226 AAD19875 CAI22285 EAW55072
RNA Seq Atlas 2295

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca