Version 5.4
Homo sapiens Gene: APOL3
Summary
InnateDB Gene IDBG-5618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOL3
Gene Name apolipoprotein L, 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128284
Encoded Proteins
IDBP-5620
apolipoprotein L, 3
IDBP-5624
apolipoprotein L, 3
IDBP-235677
apolipoprotein L, 3
IDBP-235679
apolipoprotein L, 3
IDBP-235681
apolipoprotein L, 3
IDBP-374423
apolipoprotein L, 3
IDBP-374434
apolipoprotein L, 3
IDBP-374436
apolipoprotein L, 3
IDBP-374439
apolipoprotein L, 3
IDBP-592614
apolipoprotein L, 3
IDBP-590668
apolipoprotein L, 3
IDBP-599717
apolipoprotein L, 3
IDBP-588283
apolipoprotein L, 3
IDBP-586203
apolipoprotein L, 3
IDBP-587073
apolipoprotein L, 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 6. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:36140330-36166177
Strand Reverse strand
Band q12.3
Transcripts
ENST00000361710 ENSP00000355164
ENST00000349314 ENSP00000344577
ENST00000397293 ENSP00000380461
ENST00000397289 ENSP00000380457
ENST00000397287 ENSP00000380456
ENST00000424878 ENSP00000415779
ENST00000432700 ENSP00000416732
ENST00000422426 ENSP00000409345
ENST00000426939 ENSP00000391174
ENST00000487355 ENSP00000433618
ENST00000487423
ENST00000487783 ENSP00000436331
ENST00000485453
ENST00000472303 ENSP00000432868
ENST00000534251
ENST00000531195 ENSP00000434449
ENST00000525184
ENST00000530895 ENSP00000435958
ENST00000531095 ENSP00000432271
ENST00000528740
ENST00000533061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005319 lipid transporter activity
GO:0008289 lipid binding
Biological Process
GO:0006869 lipid transport
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0042157 lipoprotein metabolic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.474737 Hs.690817
RefSeq NM_145640 NM_145641 NM_145642 XM_006724322 XM_006724324 XM_006724325
HUGO
OMIM
CCDS CCDS13922 CCDS13924
HPRD 06264
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca