Version 5.4
Homo sapiens Protein: APOL3
Summary
InnateDB Protein IDBP-235677.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOL3
Protein Name apolipoprotein L, 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380461
InnateDB Gene IDBG-5618 (APOL3)
Protein Structure
UniProt Annotation
Function May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005319 lipid transporter activity
GO:0008289 lipid binding
Biological Process
GO:0006869 lipid transport
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0042157 lipoprotein metabolic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR008405 Apolipoprotein L
PFAM PF05461
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95236
PhosphoSite PhosphoSite-O95236
TrEMBL
UniProt Splice Variant
Entrez Gene 80833
UniGene Hs.690817
RefSeq XP_006724388
HUGO HGNC:14868
OMIM 607253
CCDS CCDS13924
HPRD 06264
IMGT
EMBL AF070675 AF305227 AF324233 AF324236 AF324237 AF324238 AY014902 AY014903 AY014904 AY014905 AY014906 AY014907 BC042918 BC050596 CH471095 CR456379 Z95114
GenPept AAC83233 AAG50344 AAG50345 AAG50346 AAG50347 AAG50348 AAG50349 AAH42918 AAH50596 AAK20213 AAK26527 AAK26528 AAK26529 CAG30265 CAQ08518 CAQ08519 EAW60080

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca