Version 5.4
Homo sapiens Gene: PIK3R4
Summary
InnateDB Gene IDBG-56332.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3R4
Gene Name phosphoinositide-3-kinase, regulatory subunit 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196455
Encoded Proteins
IDBP-56334
phosphoinositide-3-kinase, regulatory subunit 4
IDBP-475923
phosphoinositide-3-kinase, regulatory subunit 4
IDBP-479012
phosphoinositide-3-kinase, regulatory subunit 4
IDBP-476319
phosphoinositide-3-kinase, regulatory subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:130678935-130746829
Strand Reverse strand
Band q22.1
Transcripts
ENST00000356763 ENSP00000349205
ENST00000511760
ENST00000512362
ENST00000512677
ENST00000508273 ENSP00000427302
ENST00000507330 ENSP00000424274
ENST00000512430 ENSP00000422767
ENST00000504834
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008286 insulin receptor signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
Cellular Component
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005930 axoneme
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032571
View Gene Order
ENSBTAG00000020787
Not yet available
Pathways
NETPATH
REACTOME
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_120918
Synthesis of PIPs at the late endosome membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_111217
Metabolism pathway
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RAC3 D6RBB7
UniProt Splice Variant
Entrez Gene 30849
UniGene Hs.149032
RefSeq NM_014602
HUGO HGNC:8982
OMIM 602610
CCDS CCDS3067
HPRD 04010
IMGT
EMBL AC097105 AC128683
GenPept
RNA Seq Atlas 30849

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca