InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3R4

Summary

InnateDB Protein

IDBP-56334.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3R4

Protein Name

phosphoinositide-3-kinase, regulatory subunit 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349205

InnateDB Gene

IDBG-56332 (PIK3R4)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.

Subcellular Localization

Late endosome {ECO:0000269PubMed:14617358}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:8999962}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008286	insulin receptor signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response

Cellular Component

GO:0005770	late endosome
GO:0005829	cytosol
GO:0005930	axoneme
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000357 HEAT
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001680 WD40 repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain
IPR021133 HEAT, type 2

PFAM

PF02985
PF00069
PF07714
PF00400

PRINTS

PR00109

PIRSF

SMART

SM00320
SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt