InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GABRG2

Summary

InnateDB Gene

IDBG-56451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRG2

Gene Name

gamma-aminobutyric acid (GABA) A receptor, gamma 2

Synonyms

CAE2; ECA2; GEFSP3

Species

Homo sapiens

Ensembl Gene

ENSG00000113327

Encoded Proteins

IDBP-56453

gamma-aminobutyric acid (GABA) A receptor, gamma 2

IDBP-56455

gamma-aminobutyric acid (GABA) A receptor, gamma 2

IDBP-381124

gamma-aminobutyric acid (GABA) A receptor, gamma 2

IDBP-475937

gamma-aminobutyric acid (GABA) A receptor, gamma 2

IDBP-473876

gamma-aminobutyric acid (GABA) A receptor, gamma 2

IDBP-474236

gamma-aminobutyric acid (GABA) A receptor, gamma 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:162067540-162155536

Strand

Forward strand

Band

q34

Transcripts

ENST00000356592	ENSP00000349000
ENST00000361925	ENSP00000354651
ENST00000414552	ENSP00000410732
ENST00000522990	ENSP00000430732
ENST00000523372	ENSP00000430124
ENST00000522053	ENSP00000430182

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0008503	benzodiazepine receptor activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0009791	post-embryonic development
GO:0030534	adult behavior
GO:0034220	ion transmembrane transport
GO:0051932	synaptic transmission, GABAergic
GO:0055085	transmembrane transport
GO:0071420	cellular response to histamine
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0032590	dendrite membrane
GO:0034707	chloride channel complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060077	inhibitory synapse
GO:1902711	GABA-A receptor complex