Homo sapiens Gene: CDK5RAP3
Summary
InnateDB Gene IDBG-56491.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK5RAP3
Gene Name CDK5 regulatory subunit associated protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108465
Encoded Proteins
CDK5 regulatory subunit associated protein 3
CDK5 regulatory subunit associated protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47967810-47981774
Strand Forward strand
Band q21.32
Transcripts
ENST00000338399 ENSP00000344683
ENST00000536708 ENSP00000438886
ENST00000578996
ENST00000584168
ENST00000581160
ENST00000578525 ENSP00000462328
ENST00000585163
ENST00000582275
ENST00000579853
ENST00000583697 ENSP00000464286
ENST00000580670 ENSP00000463442
ENST00000583182
ENST00000579175 ENSP00000463950
ENST00000584991 ENSP00000462012
ENST00000579632 ENSP00000464542
ENST00000584592
ENST00000584525
ENST00000579780
ENST00000578733
ENST00000583352 ENSP00000463431
ENST00000582482
ENST00000577664 ENSP00000464419
ENST00000581708
ENST00000578134
ENST00000584186
ENST00000578663
ENST00000579605 ENSP00000462042
ENST00000584042
ENST00000580287
ENST00000577442
ENST00000583363 ENSP00000462431
ENST00000581662
ENST00000578018 ENSP00000462886
ENST00000584063
ENST00000580391 ENSP00000463878
ENST00000577802
ENST00000582114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007420 brain development
GO:0045664 regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071569 protein ufmylation
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.20157
RefSeq NM_001278197 NM_001278198 NM_001278216 NM_001278217 NM_176096
HUGO
OMIM
CCDS CCDS42356 CCDS62232
HPRD 12190
IMGT
EMBL
GenPept
RNA Seq Atlas