Version 5.4
Homo sapiens Protein: CDK5RAP3
Summary
InnateDB Protein IDBP-56493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK5RAP3
Protein Name CDK5 regulatory subunit associated protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344683
InnateDB Gene IDBG-56491 (CDK5RAP3)
Protein Structure
UniProt Annotation
Function Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. {ECO:0000269PubMed:10721722, ECO:0000269PubMed:12054757, ECO:0000269PubMed:12737517}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007420 brain development
GO:0045664 regulation of neuron differentiation
GO:0071569 protein ufmylation
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR008491 Protein of unknown function DUF773
PFAM PF05600
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JB5
PhosphoSite PhosphoSite-Q96JB5
TrEMBL J3QL86
UniProt Splice Variant
Entrez Gene 80279
UniGene Hs.20157
RefSeq NP_788276
HUGO HGNC:18673
OMIM 608202
CCDS CCDS42356
HPRD 12190
IMGT
EMBL AB062433 AC018521 AF110322 AF217982 AF343090 AK023722 AK223387 BC009957 BC072435 CH471109
GenPept AAG17225 AAG39277 AAH09957 AAH72435 AAK69655 BAB14657 BAB93496 BAD97107 EAW94772 EAW94774 EAW94775 EAW94778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca