Homo sapiens Gene: SERPINB1
Summary
InnateDB Gene IDBG-56586.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB1
Gene Name serpin peptidase inhibitor, clade B (ovalbumin), member 1
Synonyms EI; ELANH2; HEL57; LEI; M/NEI; MNEI; PI-2; PI2;
Species Homo sapiens
Ensembl Gene ENSG00000021355
Encoded Proteins
serpin peptidase inhibitor, clade B (ovalbumin), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:2832332-2842006
Strand Reverse strand
Band p25.2
Transcripts
ENST00000380739 ENSP00000370115
ENST00000468511
ENST00000490094
ENST00000476896
ENST00000460260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Amoebiasis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_030666 XM_006715008
HUGO
OMIM
CCDS CCDS4477
HPRD 00555
IMGT
EMBL
GenPept
RNA Seq Atlas