Mus musculus Gene: Serpinb1a
Summary
InnateDB Gene IDBG-142542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpinb1a
Gene Name serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms 1190005M04Rik; AI325983; EI; EIA; ELANH2; LEI; M/NEI; MNEI; PI2;
Species Mus musculus
Ensembl Gene ENSMUSG00000044734
Encoded Proteins
serine (or cysteine) peptidase inhibitor, clade B, member 1a
serine (or cysteine) peptidase inhibitor, clade B, member 1a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000021355:
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:32842092-32851185
Strand Reverse strand
Band A3.2
Transcripts
ENSMUST00000091668 ENSMUSP00000089257
ENSMUST00000076352 ENSMUSP00000075690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Amoebiasis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Amoebiasis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9D154
TrEMBL
UniProt Splice Variant
Entrez Gene 66222
UniGene Mm.20144
RefSeq NM_025429 XM_006516724
OMIM
CCDS CCDS26428
HPRD
IMGT
MGI ID MGI:1913472
MGI Symbol Serpinb1a
EMBL AF426024 AF521697 AK003930 AK004500 AK008914 AK160167 AK160456 AL645808 BC011140 BC104333
GenPept AAH11140 AAI04334 AAL57486 AAM95933 BAB23079 BAB23335 BAB25964 BAE35668 BAE35797 CAI25648
RNA Seq Atlas 66222