Version 5.4
Homo sapiens Gene: TOMM40
Summary
InnateDB Gene IDBG-56765.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOMM40
Gene Name translocase of outer mitochondrial membrane 40 homolog (yeast)
Synonyms C19orf1; D19S1177E; PER-EC1; PEREC1; TOM40
Species Homo sapiens
Ensembl Gene ENSG00000130204
Encoded Proteins
IDBP-56767
translocase of outer mitochondrial membrane 40 homolog (yeast)
IDBP-294347
translocase of outer mitochondrial membrane 40 homolog (yeast)
IDBP-381698
translocase of outer mitochondrial membrane 40 homolog (yeast)
IDBP-764163
IDBP-761787
IDBP-763822
IDBP-765049
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:44890569-44903689
Strand Forward strand
Band q13.32
Transcripts
ENST00000252487 ENSP00000252487
ENST00000405636 ENSP00000385184
ENST00000426677 ENSP00000410339
ENST00000592041 ENSP00000465608
ENST00000592434 ENSP00000466084
ENST00000589649 ENSP00000465032
ENST00000589253 ENSP00000465611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008320 protein transmembrane transporter activity
GO:0015288 porin activity
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0006811 ion transport
GO:0044267 cellular protein metabolic process
GO:0055085 transmembrane transport
GO:0071806 protein transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005742 mitochondrial outer membrane translocase complex
GO:0016021 integral component of membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0032592 integral component of mitochondrial membrane
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002984
View Gene Order
ENSBTAG00000001781
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655909
RefSeq NM_001128916 NM_001128917 NM_006114 XM_005258411
HUGO
OMIM
CCDS CCDS12646
HPRD 16274
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca